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225 Inhibition of NETosis with PAD4 and DNase I inhibitors has shown promise in enhancing CD8 + T cell infiltration, reducing tumor growth, and improving the cellular response to anti-PD-1 blockade therapy in colorectal cancer

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Using tissue from donors, the team observed that cells in the nucleus pulposus, a jelly-like structure at the center of intervertebral discs, had a lower amount of this peptide receptor when degeneration increased

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Similarly, in neurons from locus coeruleus no significant role of arrestin 3 was evidenced in acute MOR desensitization upon [Met 5 ]-enkephalin exposure on the activation of K + currents (Dang et al., 1999) or KOR (Appleyard et al., 1998)