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The absence of clear symptoms means that elevated B12 is usually detected incidentally during blood tests performed for other clinical indications

Diagnosis is primarily clinical and needs immediate action because it can be potentially fatal despite its very low incidence

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The single most important framing: efficacy figures for this molecule come from cell and animal studies , so any timeline is a research expectation, not a guaranteed outcome

For oral cobalamin supplementation: Protocol: Daily administration for a total of 12 weeks and re-check the serum cobalamin concentration 4 weeks after stopping supplementation