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Tsai J-C, Perrella MA, Yoshizumi M, Hsieh C-M, Haber E, Schlegel R, and Lee M-E (1994)

The median duration of postinjection catheterization for these patients treated with BOTOX 200 Units (n = 33) was 289 days (minimum 1 day to maximum 530 days), as compared to a median duration of 358 days (minimum 2 days to maximum 379 days) for patients receiving placebo (n = 7)

The glucagon receptor component adds energy expenditure and lipolysis effects not seen in dual agonists, which may explain the larger effect sizes in Phase II data

SERCA, Sarco/endoplasmic reticulum Ca 2+ -ATPase inhibitor

Changes in sodium concentration play a pivotal role in deciding the type of fluid depletion (figure 4): Hyponatremic and hypotonic dehydration [5, 6]: The development of hyponatremia reflects net solute loss in excess of water loss