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Although anti-cancer therapy targeting metabolism has achieved some gratifying results, it is still currently believed that this field has the following shortcomings for possible future breakthroughs: 1) The side effects of such drugs limit their clinical effects as the optimal dose window is hard to be determined

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effects mediated mainly via ERR in cardiomyocytes

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This occurs when the ligament holding the esophagus and stomach to the diaphragm breaks down and can cause symptoms of acid reflux, difficulty swallowing, regurgitation of food, or cause the stomach to be cut off from its blood supply