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Dummler et al., 2005

What are common methylfolate side effects

OHalloran J Am Chem Soc 141:64536457 Zhao QH, Zhang Y, Liu Y, Wang HL, Shen YY, Wen (2010) Med Oncol 27:203212 Lu DP, Qiu JY, Jiang B, Wang Q, Liu KY, Liu YR, Chen SS (2002) Blood 99:31363143 Kumagai Y, Sumi D (2007) Annu Rev Pharmacol Toxicol 47:243262 Frampton JE (2022) Drugs 82:16031609 Ramsay EE, Dilda PJ (2014) Fron Pharmacol 5:181181 Manshouri T, Kala SV, Ashoori F, Zingaro R, Freireich EJ, Andreeff M, Kantarjian HM, Verstovsek S (2005) Blood 106:190b190b Mann KK, Wallner B, Lossos IS, Miller WH Jr

et al.(2015) High performance molecular simulations through multi-level parallelism from laptops to supercomputers

Key genes modulated by GHK-Cu include: Genes encoding growth factors (FGF, VEGF, TGF-) Collagen and extracellular matrix proteins (COL1A1, COL3A1, ELN) Anti-inflammatory and antioxidant enzymes (SOD, catalase) Cell adhesion and communication molecules Collagen & Extracellular Matrix Synthesis Collagen synthesis is fundamental to GHK-Cu's regenerative effects