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10.1016/j.phymed.2022.153942 32 GuoM.WangZ.DaiJ.FanH.YuanN.GaoL.et al (2023)

Macrophage activation is central to PNI pathogenesis, transitioning from a proinflammatory (M1) to an anti-inflammatory (M2) phenotype with distinct functions in inflammation and repair

La phase I, assure par les enzymes de la famille des cytochromes P450, transforme les composs lipophiles en intermdiaires ractifs, souvent plus toxiques que les molcules d'origine