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The peptide binds to GHRH receptors on somatotroph cells in the anterior pituitary, triggering a cascade that increases intracellular calcium and activates protein kinase C, which then causes vesicular fusion and GH secretion into circulation
[47] Circulation reduced blood flow to the brain, [48] [49] [50] [51] [52] [53] [54] [55] even in the absence of POTS/NMH [56] reduced blood flow to the heart [57] [58] peripheral endothelial dysfunction, which is an established risk factor for cardiovascular disease [59] Blood vessels Blood reduced blood volume [60] [61] abnormally shaped of red blood cells [62] [63] reduced oxygen uptake in hemoglobin [64] Digestive system Gastrointestinal tract lower levels of Bifidobacteria, Escherichia coli and higher levels of aerobic bacteria, [65] in particular Enterococcus and Streptococcus species [66] higher levels of enterococcus bacteria in CFS patients were associated with more severe neurological and cognitive dysfunction [67] Significantly increased proportions of Firmicutes [68] [69] and Bacteroides [69] CFS patients may suffer from small intestinal bacterial overgrowth (SIBO) at high rates [70] Higher levels of serum IgA and IgM against lipopolysaccharides (LPS), a major component of the outer membrane of gram-negative bacteria, indicating translocation
[DOI] [PMC free article] [PubMed] [Google Scholar] 189.Sndergrd S.D., Cintin I., Kuhlman A.B., Morville T.H., Bergmann M.L., Kjr L.K., Poulsen H.E., Giustarini D., Rossi R., Dela F., et al
