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In a clinical trial of patients with severe sepsis, despite the fact that the death rate was lower in AT-treated individuals with DIC who were not administered heparin (98), high-dose AT concentrates did not improve the total mortality (99)

This raises intriguing questions as to whether Moco uptake occurs in other animals, and if any regulatory crosstalk exists between Fe-S clusters depletion and environmental Moco acquisition

Yuen MF, Chen CY, Liu CJ, Jeng WJ, Elkhashab M, Coffin CS, Kim W, Greenbloom S, Ramji A, Lim YS, Kim YJ, Fung SK, Kim DJ, Jang JW, Lee KS, Iyer RP, Macfarlane C, Jackson K, Locarnini SA, Chan HLY, Afdhal NH

This step is followed by treatment with an azide-tagged fluorophore, after which cellular fluorescence is measured using a flow cytometer or a plate reader in 96- or 384-well plates

Plant Cell Environ 47(12):50675075