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Currently, several pharmaceutical companies are investigating specific SIRT1 activators in Phase I and Phase II trials for the treatment of type II diabetes and obesity (228) to define their utility in the treatment of obesity and metabolic diseases

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Moreover, low picomolar PregS concentrations appear to be sufficient to increase [Ca 2+ ]i and CREB phosphorylation ( Figure 2 Effects of PregS on NMDARs are diverse ( A Rs (110)

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