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For example, the WHO FCTC has significantly reduced smoking prevalence since it was put into force in 2005 by promoting tax increases, public place smoking bans, and tobacco package warning policies ( DALYs and deaths were significantly higher in men than in women, consistent with the longstanding historical pattern of higher smoking prevalence than in women globally ( In 2021, ASR DALYs and ASR mortality rates peaked at 6569 and 7074 years old and then decreased, consistent with the long-term incubation period for tobacco-attributable cancers ( The tobacco-attributable cancer burden was strongly correlated with SDI levels, with the highest 2021 ASR-DALYs in medium-SDI to high-SDI areas (2,426.26/100,000) and the lowest in low-SDI areas (551.12/100,000)

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