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In general, however, clinicians should not hesitate to encourage patients with mental health problems to quit smoking

Novel high-throughput single-cell approaches, including RNA 171 and bisulphite sequencing 172 , as well as assay for transposase-accessible chromatin (ATAC) 173 and Cleavage Under Targets and Tagmentation (CUT&Tag) 174 allow transcriptomic and epigenomic profiling of low-input heterogeneous tissue at single-cell or -nucleus resolution

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