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An upright position allows gravity to assist with gastric emptying, which reduces the bloated, overly full feeling that triggers nausea

It helps regulate blood sugar, appetite, and digestion

In vitro experiments revealed that high glucose-conditioned hippocampal neurons inhibited the differentiation of NSCs, and the application of an anti-RGMa antibody restored it

While semaglutide and tirzepatide are currently the most established options, newer molecules are emerging that may eventually offer different dosing profiles and outcomes

In situations when the emergency provider is not X-waivered and next day follow-up cannot be guaranteed, the patient can be directed to return to the ED for subsequent doses of buprenorphine (up to 72 hours after initial presentation) until outpatient follow-up and long term MOUD can be established