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To study the relevance of AKT-dependent effects we treated the cells with the specific AKT-inhibitor MK2206 ( Figure S2 ) to access the AKT-regulated antioxidant defense capacity upon IR in our AKT-WT and activated AKT-E17K mutant TrC1 isogenic cell line models

Insulin-like growth factor 1, but not growth hormone, has in vitro proliferative effects on neonatal foreskin fibroblasts without affecting 5-alpha-reductase or androgen receptor activity

doi: 10.1038/s41589-019-0408-1 149 WortmannMSchneiderMPircherJHellfritschJAichlerMVegiNet al

10.1016/j.ejcb.2019.151058 Eur

Consulting Psychologists Press, Inc., Palo Alto, Ca Yildiz-Yesiloglu A, Ankerst DP (2006) Neurochemical alterations of the brain in bipolar disorder and their implications for pathophysiology: a systematic review of the in vivo proton magnetic resonance spectroscopy findings