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It is thought that 5hmC is particularly crucial in the brain due to its high abundance there compared to other organs (Li and Liu, 2011) and its enrichment in synapse-related genes (Khare et al., 2012)

Primary motor cortices of 90 days old (P90) prpTDP-43 A315T and healthy wildtype (WT) control mice were dissected out and metabolites were isolated by methanol extraction method followed by high performance mass spectrometry profiling of metabolites (Fig

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