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A.WheatonK.LinY.MaW.XuanW.et al (2011)

Patients characteristically present with painless hematuria , though clot formation or ureteral obstruction by the tumor mass can occasionally precipitate renal colic

Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production

While these effects reduce cancer cell survival, normal cells like human dermal fibroblasts and gastric mucosal cells exhibit higher viability and faster DNA repair when exposed to similar doses, suggesting that SF could be an effective cancer therapeutic without harming normal cells (153, 154)