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This initial functional assignment was based on a classification established for scorpion venom enzymes, and the following six functional classes are recognized: 1) toxic enzymes that are used in hunting and defense, 2) pre-digestive enzymes that break down tissue and support extra-intestinal digestion, 3) spreading factor enzymes that support the uptake of co-secreted toxins, 4) venom component activators that are involved in protein maturation, 5) preservative enzymes that defend the venom gland against noxious molecules, 6) multifunctional enzymes (Delgado-Prudencio et al., 2022)

SARS-CoV-2 infection exacerbates this metabolic imbalance and predisposes these patients to the severe pathophysiologies of COVID-19, including the involvement of NETs (neutrophil extracellular traps) and HA overproduction in the lung

Mediastinoscopy with biopsy

Zhang YL, Guo H, Zhang CS, et al

21:153 (2022) Lawrence CW, Christensen R, Schwartz A