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Additionally, we assessed the levels of lactate and pyruvate and the activities of LDH and PK to comprehensively understand the specific impacts of Irisin on lactate metabolism under conditions of SIRT1 knockdown (Fig

The current literature points to GCase activity and lysosomal function as major players in the role of immune cells in PD, however significant gaps in our understanding remain, in particular regarding how different GBA1 mutations may not produce a uniform phenotype

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