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To systematically identify 20S proteasome substrates under native conditions, we used an advanced mass spectrometry (MS) approach coupled to biochemical and cellular analysis

2020;318:L77386

Morita K, Wang F, Patel K, Bueso-Ramos CE, Zahr AA, Gumbs C, Zhang J, Song X, Mendoza M, Wu CJ, Kornblau S, DiNardo CD, Ravandi F, Garcia-Manero G, Jabbour E, Andreeff M , Kantarjian HM, Konopleva M, Futreal A, Takahashi K

Alzheimer disease pathology reduction The most extensive body of P21 research has been conducted in the 3xTg-AD mouse model, a transgenic strain that develops both amyloid-beta plaques and tau tangles, closely mimicking human Alzheimer disease pathology

In contrast, AtHTL unexpectedly did not interact with AtMAX2 in a KAR 1 -dependent manner