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At low ROS levels apoptosis was blocked, whereas increased cellular ROS levels restored ATM/JNK-mediated apoptotic signaling [143]

In 2015, a post hoc exploratory analysis of subjects enrolled in the PANTHER-IPF clinical trial was conducted to determine whether specific polymorphisms in toll-interacting protein ( TOLLIP ) and MUC5B genes modified the efficacy of NAC

doi: 10.1038/nprot.2006.339 33 ParkJ-HKimY-HParkE-HLeeS-JKimHKimAet al

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Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial