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10.1089/ars.2005.7.999 60 HurdT

For example, abnormal methylation of certain transcription factors could cause the inactivation of tumor suppressor genes, while abnormal acetylation in some enhancer regions may promote the expression of oncogenes

somnifera by intraperitoneal route (4 mg/kg body weight) 5 times for 2 weeks markedly suppresses MDA-MB-231 tumor weight as well as exhibited reduced cell proliferation and increased apoptosis compared with tumors from control mice (Stan et al., 2008b)In cervical cancer using xenograft mouse model, it was observed that i,p treatment of withaferin A (8 mg/kg body weight) for 6 weeks resulted in 70% reduction in tumor size compared to controls as well as heightened expression of p53 and lowered expression of pro-caspase 3/Bcl2(Suman et al., 2016)