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Summary Keywords monocyte-derived alveolar macrophages, single-cell RNA-sequencing, COPD, lung inflammation, IRAK4 inhibitor, neutrophils, smoking, tissue remodeling Citation Wohnhaas CT, Baler K, Watson CK, Shen Y, Leparc GG, Tilp C, Heinemann F, Kind D, Stierstorfer B, Deli D, Brunner T, Gantner F, Schultze JL, Viollet C and Baum P (2024) Monocyte-derived alveolar macrophages are key drivers of smoke-induced lung inflammation and tissue remodeling

Acknowledgements We thank Drs Yutaka Kiyohara, Yasufumi Doi, Toshiharu Ninomiya, Shigenobu Kanba, Dongchon Kang, Shuzo Kumagai, Chisa Matsumoto, Yuji Komorita (Kyushu University), Nobutaka Tsutsu, Nobuhiro Sasaki (Fukuoka Red Cross Hospital), Kiyohide Nunoi, Yuichi Sato, Yuji Uchizono, Ayumi Yamauchi, Kaori Itoh, Chie Miyagawa (St Marys Hospital), Sakae Nohara, Hirofumi Imoto, Kazushi Amano, Chie Kitaoka (Steel Memorial Yawata Hospital), Daisuke Gotoh, Toshitaka Himeno, Masae Toyonaga (Kyushu Central Hospital), Noriyasu Shinohara, Ayako Tsutsumi (Fukuoka Higashi Medical Centre), Masahiro Nakano, Mina Matsuo, Shoko Morimoto, Tomoko Hyodo (Hakujyuji Hospital), Masae Minami (Clinic Minami Masae), Miya Wada (Wada Miya Naika Clinic), Yoshifumi Yokomizo (Yokomizo Naika Clinic), Masanori Kikuchi (Kikuchi Naika Clinic), Riku Nomiyama (Suzuki Naika Clinic), Shin Nakamura (Nakamura Naika Clinic), Kenji Tashiro (Oshima Eye Hospital), Mototaka Yoshinari (Yoshinari Naika Clinic), Kojiro Ichikawa (Fukutsu Naika Clinic) and Teruo Omae (Hisayama Research Institute For Lifestyle Diseases), clinical research coordinators

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Univariate, bivariate and multivariate analytical techniques were employed to examine the study hypotheses

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