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The reversal of these effects by the MG scavenger SC confirmed MGs central causative role

Moreover, MenSCs from patients presented higher expression levels of the surface markers CD9, CD10, and CD29 than those from healthy individuals did, along with increased proliferative and invasive capacities (Nikoo et al., 2014)

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The subsequent buildup of lipofuscin, characteristic of lysosomal aggregates, is associated with metabolic disruptions and impaired autophagic function, establishing it as a key biomarker for cellular aging 29