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Description

10.1111/j.1365-3040.2011.02400.x 88 OelzeM

Cellular deconvolution of bulk transcriptomic data from the peri-infarct cortex showed that cells with molecular signature similar to the so-called disease-associated astrocytes, originally described in the vicinity of -amyloid plaques in a mouse model of AD and in the aged brain 464 , are present also in post-stroke tissue 383

Most notably, ALA upregulates gamma-glutamylcysteine ligase (-GCL), the rate-limiting enzyme required for the synthesis of glutathionethe body's master intracellular antioxidant