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At stage 4, natural tissue regeneration is going to be much more challenging, but luckily, there are new options that exist that can accelerate thyroid tissue repair ( see my article about lasers for tissue regeneration to learn about experimental strategies that may help)

Flotte TR, Zeitlin PL, Reynolds TC, Heald AE, Pedersen P, Beck S, Conrad CK, Brass-Ernst L, Humphries M, Sullivan K, Wetzel R, Taylor G, Carter BJ, Guggino WB (2003) Phase I trial of intranasal and endobronchial administration of a recombinant adeno-associated virus serotype 2 (rAAV2)-CFTR vector in adult cystic fibrosis patients: a two-part clinical study

Lamberto F, Peral-Sanchez I, Muenthaisong S, Zana M, Willaime-Morawek S, Dinnys A

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As the in-vivo evidence discussed later shows, however, this isolated synthetic peptide versus E-domain expressed in context distinction turns out to be one of the most important and least appreciated fault lines in the entire field