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Those receiving 150 mg canakinumab had a 15% lower risk of heart attack, stroke, or death from cardiovascular causes compared with placebo

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Over time, medications may become less effective, the attacks may last longer, or pain may begin to appear between attacks

Additionally, fractionation of radiotherapy, which involves dividing the total radiation dose into multiple smaller doses administered over several sessions, has been shown to improve therapeutic outcomes and reduce neurotoxicity