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Interestingly, naive hESCs show high expression of nicotinamide N -methyltransferase (NNMT), which consumes SAM to methylate nicotinamide, thereby lowering SAM and enforcing a hypomethylated H3K27me3-low state associated with naive pluripotency 29

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B12 supplementation is generally regarded as safe and unlikely to cause harm to most people as there is no risk of overdose