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It is possible that changes in the globus pallidus do not appear until advanced stages of the disease 42

[14] The EXCEL results generated substantial controversy

Given the established health benefits of consuming at least two servings of oily fish per week, providing approximately 400 to 500 mg EPA + DHA, some researchers have proposed that the US National Academy of Medicine establish dietary reference intakes (DRIs) for EPA + DHA (27)

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*Correspondence: Cesare Indiveri, [email protected] This article was submitted to Mitochondrial Research, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers