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2013 Mar 25;76:81-6

[PubMed 234414] 353

Gut microbiome and health: mechanistic insights

In the heterotetrameric structure of Bacillus (Geobacillus) stearothermophilus pyruvate dehydrogenase, a Gram-positive bacterium, each thiamine pyrophosphate molecule binds between the N-terminal domains of an and a subunit, at the end of a funnel-shaped channel 21 deep that leads to the active site