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Pat No 6,747,009of the formula I: wherein Z=CH 2 and Y=CH 2 , or Z=O and Y=C, R 1 and R 2 are independently selected from the group consisting of H, linear or branched alkyl (1-25C), aralkyl (6-26C), cycloalkyl (6-25C), heterocycles (6-20C), ethers or polyethers (3-25C), and where R 1 -R 2 together have 2-20C atoms and form a macrocycle with the remainder of formula I

Other modulators of IGF-1 activity such as exercise (38) and sleep (39) have been also documented, but more work is needed to better define their role in IGF-1 physiology as they exert nuanced actions

PubMed Central, Chin, Dawn, et al

Maintenance of mitochondrial function

Graham WV, Wang F, Clayburgh DR, Cheng JX, Yoon B, Wang Y, et al