bpc-157 clinical trial humans randomized and the Difference Between an Evidence Gap and a Cover-Up: What the entire human evidence base actually looks like, and the questions to ask next. — WellFounded BPC-157 – Prime Human Labs

The SURMOUNT-1 trial, published in the New England Journal of Medicine, randomized 2,539 adults with obesity or overweight to tirzepatide 5 mg, 10 mg, or 15 mg weekly for 72 weeks

Temmerman L, Slonimsky E, Rosenthal N (2010) Class 2 IGF-1 isoforms are dispensable for viability, growth and maintenance of IGF-1 serum levels

One day off per week is too muchthe system cant recover. This pattern mimics physiologic rhythm while supporting hippocampal neuroplasticity

NAD+ levels decline with age, leading to altered metabolism and increased disease susceptibility, which has spurred interest in NAD+-boosting molecules to enhance health and longevity

Results Body weight, fat mass, and cecal mass As expected, obese mice (maintained on an HFD followed by WD) had significantly higher body weights than mice continuously maintained on LD