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In the hypoxic environment, the phenotype of smooth muscle cells changes from contractile to synthetic, which increases the cells proliferation and migration capabilities

Moreover, this study found that the catalytic triad of GPx4 is located on a flat surface surrounded by basic amino acid patches, K48/K135/R152/T139, and this particular conformation supports its broad-spectrum substrate specificity, and several studies have demonstrated that the molecular weight of GPx4 proteins is 19-22 kDa

Use of dipeptides for the synthesis of glutathione by astroglia-rich primary cultures