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It formally characterises DSIP as a still unresolved riddle acknowledging that no specific DSIP receptor has been confirmed, that the existence of DSIP-like endogenous peptides distinct from DSIP itself may account for a substantial proportion of DSIP-like immunoreactivity data, and that the most robust SWS-promoting activity in rodent studies has been demonstrated for synthetic DSIP structural analogues rather than native DSIP itself

However, for significant improvements, continued use for at least one to three months under medical supervision is ideal

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(2021) reported superior pain relief at 3 months compared with corticosteroids at 25% concentration of dextrose [61], Mohamed et al

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