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In other embodiments, enzymes and amino acids are contemplated for use as a membrane particle, and include, but are not limited to, alpha galactosidase, amylase, bromelain, cellulase, papain, peptidase, protease, proteolytic enzymes, superoxide dismutase, trypsin, betaine, casein, glutamic Acid, L-alanine, L-arginine, L-cysteine, L-glutamine, L-glycine, L-histidine, L-isoleucine, L-leucine, L-lysine, L-methionine, L-ornithine, L-phenylalanine, L-proline, L-taurine, L-threonine, L-tryptophan, L- tyrosine, L-valine, N-acetly-L-cysteine, protein soluble soy, soy protein isolates, and whey protein isolates

The impact of the JAK/STAT pathway on macrophage polarization has been highlighted in recent years, with JAK inhibitors reducing the secretion of proinflammatory cytokines IFN- and TNF-, thereby shifting macrophage polarization towards an M2 phenotype (247)

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