Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG4)-MMAE Size:1mg Product Name Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8) Synonyms CAS

Product Name Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8) Synonyms CAS Number Related CAS Molecular Formula C56H94N8O21 Molecular Weight 1215

Chloropyrimidine (CP) derivatives generally exhibit better cell permeability compared to their benzylguanine (BG) derivatives

CA-Oregon Green is a cell permeable HaloTag fluorescent ligand and can be used to label intracellular proteins (496Ex/516Em after hydrolysis)

351 SMILES CC(C)(C)OC(=O)CN1CCN(CCN)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Locally Advanced or Metastatic Breast Cancer

Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG4)-MMAE Size:1mg Product Name Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8) Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly