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L.Le GallG.BrancaJ

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Brain 147 , 16531666

Regarding acute toxicity, according to the 2023 National Poison Data System annual report, there were 7905 reported unintentional heavy metal exposures in the United States, resulting in 26 serious health outcomes and two deaths

While challenges persist regarding incomplete understanding of regulatory networks and nanocarrier biosafety issues, this review not only provides a theoretical framework for comprehending ferroptosis-mediated anti-GBM mechanisms but also outlines future research directions, including in-depth dissection of ferroptosis signaling hubs, development of intelligent nano-delivery systems, and establishment of preclinical safety evaluation protocols