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These will be explored as part of future studies

We propose a mechanism to better explain the downstream pathophysiological events in AD powered by age-related intracellular aggregation of amyloid- (A) in the vesicular trafficking system initiated by an oxidative shift in redox state that lowers bioenergetic capacity [2, 3]

The saliva was collected before any intraoral intervention (examination, brushing, etc.)

Eur J Pharmacol 187:201207 Miller GW, Gainetdinov RR, Levey AI, Caron MG (1999) Dopamine transporters and neuronal injury

Importantly, these studies demonstrate that the inactivation of mTORC1 is not a passive process, due to the absence of positive signals, but rather involves the active participation of key cellular mechanisms, such as the nutrient starvation- and stress-induced lysosomal relocalization of the TSC complex