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In summary, lisinopril enable to activate BI1 expression in vivo and address multiple facets of ALS pathologyfrom metabolic dysregulation and fibrotic progression to autophagic fluxthrough divergent TGF--mediated pathways

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doi: 10.3389/fmicb.2026.1810261 Received 13 February 2026 Revised 25 March 2026 Accepted 31 March 2026 Published 01 May 2026 Volume 17 - 2026 Edited by Wang Yiwen, Tianjin University, China Reviewed by Antonio Diez Juan, Vitrolife, Sweden Prachi Mehta, Girijananda Chowdhury University, India Updates Copyright 2026 Li, Lin, Liu, Zhang, Wang, Liang, Wang, Duan and Chen

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