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Immunohistochemistry for the cancer cell marker cytokeratin, the proliferation marker PCNA and the apoptosis marker TUNEL, revealed that HGF/c-MET inhibition per se had no effect on cancer cell number

However, as HF evolves, alterations of mitochondrial functions [3] and modulations of pyruvate metabolism (probably due to changes in PDH activity/expression, pyruvate transport and NADH shuttle [140]) occur and lead to a stage in which this switch is no longer adapted to support suitable energy production

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and/or * Influencing, controlling or preventing conception in persons

2003 May;1(5):1089-95